于正森（教授/硕士生导师）
研究方向：抗感染药物设计、合成；生物活性天然化合物的提取、分离
联系方式：yuzhengsen@hebau.edu.cn
|荣誉称号
太行学者三层次引进
|主讲课程
微生物药物学、药物合成
|教育背景
2004-2008年 18luck新利手机版iso 本科
2008-2011年 兰州大学功能有机化学国家重点实验室 硕士
2014-2019年 清华大学药学院生物学博士
|主持课题
1. 国家自然科学基金1项，2021.1-2024.12，63万
2. 河北省自然科学基金1项，2020.1-2022.12 ，10万
3. 18luck新利手机版iso 人才引进1项，2019.12-2024.12，30万
|代表性学术成果
2018年9月，在CELL期刊发表《甲羟戊酸通路是新的疫苗佐剂制药靶点》的药学研究论文，并揭示详细的分子机制。基于甲羟戊酸激酶缺乏症这一罕见病，我们首次提出并证实甲羟戊酸通路是可以作为佐剂开发的代谢通路，作用于该通路的疫苗佐剂在小鼠流感、癌症模型中显示出较现用铝佐剂更好的保护效果。
发明专利：
1.申请中：CN202110478872.9，一种wittig-hornor试剂的制备方法，发明人：于正森，王小清、于飞，杨芳，赵文卓。
2.申请中：CN108289902，作为高效的疫苗佐剂的甲羟戊酸通路抑制剂，发明人：张永辉，夏赟，谢永华，于正森，周晓英，李鑫，李丽平，杨云云，高看照，王科，刘万里，赵萌。
3. 申请中：CN109666637，Vγ9Vδ2 T及其激动剂在治疗肝纤维化、肝硬化和肝癌中的应用，发明人：张永辉，周晓英，肖鸿颖，李丽平，谢永华，于正森。
4. 申请中：WO2019076269A1，甲羟戊酸通路抑制剂及其药物组合物，发明人：张永辉，周晓英，肖鸿颖，夏赟，谢永华，于正森。
近期论文：
1.Xiaoqian Deng#, ShijunTian#,ZhengsenYu#, LiliWang, RuiyingLiang, YanbaiLi, RongXiang, ShiboJiang*, TianleiYing*, FeiYu*, Development of Small-molecule Inhibitors Against Hantaviruses,Microbes and Infection,2020,22, 272-277 (First co-author,IF = 2.373, 3区).
2. Shuai Han, Xin Li, Xia Yun,Zhengsen Yu, Ningning Cai, Satich R. Malwal, Xu Han, Eric Oldfield*, Yonghui Zhang*, Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells,Journal of Medicinal Chemistry,2019,62(23): 10867-10896 (IF = 6.253,2区Top).
3. Yun Xia#, Yonghua Xie#,Zhengsen Yu#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, and Yonghui Zhang*, The Mevalonate Pathway is a Druggable Target for Vaccine Adjuvant Discovery,Cell,2018,175(4), 1059-1073 (First co-author, IF = 36.216, 1区Top).
4. Chunchi Chen, Xiangying Hu, Xueke Tang, Yunyun Yang, Tzu Ping Ko, Jian Gao, Yingying Zheng, Jianwen Huang,Zhengsen Yu, Liping Li, Shuai Han, Ningning Cai, Yonghui Zhang, Weidong Liu, Rey-Ting Guo*, The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement,Angewandte Chemie,2018,130(46): 15280-15284 (IF = 12.257, 1区Top).
5. Xianhao Liu, Lilin Hou, Jinfeng Wang, Bin Liu,Zhengsen Yu, Liqian Ma, Shaopeng Yang, Guangsheng Fu*, Plasmonic-enhanced Polymer Solar Cells with High Efficiency by Addition of Silver Nanoparticles of Different Sizes in Different Layers,Solar Energy,2014,110, 627-635 (IF = 4.674, 2区).
6.Zhengsen Yu, Lijuan Ma, Wei Yu*, Phenyliodine Bis(trifluoroacetate) Mediated Intramolecular Oxidative Coupling of Electron-Rich N-Phenyl Benzamides,Synlett.,2012,10, 1534-1540 (IF = 2.418, 3区).
7.Zhengsen Yu, Xuhui Ju, Junyan Wang, Wei Yu*, Iodobenzene Mediated Intramolecular Oxidative Coupling of Substituted 4-Hydroxyphenyl-N-phenylbenzamides for the Synthesis of Spirooxindoles,Synthesis,2011,6, 860-866 (IF = 2.867, 3区).
8.Zhengsen Yu, Lijuan Ma, Wei Yu*, Ag2O-Mediated Intramolecular Oxidative Coupling of Acetoacetanilides for the Synthesis of 3-Acetyloxindoles,Synlett.,2010,17, 2607-2610 (IF = 2.418, 3区).
9. Junyan Wang, Xianpei Wang,Zhengsen Yu, Wei Yu*, The Synthesis of Polysubstituted Pyrroles via the Coupling of Phenyliodonium Ylides and Enamine Esters,Adv. Syn & Cata.,2009,351(13), 2063-2066 (IF = 5.1, 2区Top).
